Studies on polar cell wall growth and antibiotic susceptibility of Corynebacterium glutamicum
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چکیده
........................................................................................................................... XI Zusammenfassung ......................................................................................................... XIII List of Publications ........................................................................................................... XV Contributions to Publications ........................................................................................... XVI
منابع مشابه
DivIVA is required for polar growth in the MreB-lacking rod-shaped actinomycete Corynebacterium glutamicum.
The actinomycete Corynebacterium glutamicum grows as rod-shaped cells by zonal peptidoglycan synthesis at the cell poles. In this bacterium, experimental depletion of the polar DivIVA protein (DivIVA(Cg)) resulted in the inhibition of polar growth; consequently, these cells exhibited a coccoid morphology. This result demonstrated that DivIVA is required for cell elongation and the acquisition o...
متن کاملDivIVA is required for polar growth in the MreB - lacking rod - shaped 3 actinomycete Corynebacterium glutamicum 4 5
1 2 The actinomycete Corynebacterium glutamicum grows as rod-shaped cells by zonal 3 peptidoglycan synthesis at the cell poles. In this bacterium, experimental depletion of the 4 polar DivIVA CG protein resulted in the inhibition of polar growth; consequently, these cells 5 exhibited a coccoid morphology. This result demonstrated that DivIVA is required for cell 6 elongation and the acquisition...
متن کاملInteraction sites of DivIVA and RodA from Corynebacterium glutamicum
Elongation growth in actinobacteria is localized at the cell poles. This is in contrast to many classical model organisms where insertion of new cell wall material is localized around the lateral site. We previously described a role of RodA from Corynebacterium glutamicum in apical cell growth and morphogenesis. Deletion of rodA had drastic effects on morphology and growth, likely a result from...
متن کاملA mutation in the Corynebacterium glutamicum ltsA gene causes susceptibility to lysozyme, temperature-sensitive growth, and L-glutamate production.
The Corynebacterium glutamicum mutant KY9714, originally isolated as a lysozyme-sensitive mutant, does not grow at 37 degrees C. Complementation tests and DNA sequencing analysis revealed that a mutation in a single gene of 1,920 bp, ltsA (lysozyme and temperature sensitive), was responsible for its lysozyme sensitivity and temperature sensitivity. The ltsA gene encodes a protein homologous to ...
متن کاملDevelopment of A Novel Gene Expression System for Secretory Production of Heterologous Proteins via the General Secretory (Sec) Pathway in Corynebacterium glutamicum
Background: Corynebacterium glutamicum (C. glutamicum) is a potential host for the secretory production of the heterologous proteins. However, to this date few secretion-type gene expression systems in C. glutamicum have been developed, which limit applications of C. glutamicum in a secretory production of the heterologous proteins.Objectives: In this stu...
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تاریخ انتشار 2015